适合人群
适合年级 (Grade): 高中生/大学生
适合专业 (Major): 动物学、动物医学、兽医学、免疫学、生物学、生理学等生命科学专业或对上述专业感兴趣的学生。学生需要具备细胞学、免疫学、分子生物学基础。
建议选修: 生物学与生命科学
导师介绍
Martin
牛津大学 University of Oxford
终身正教授
Martin教授现任牛津大学Nuffield医学系终身正教授、兼任瑞士伯尔尼 Inselspital RIA 免疫学系主任、伯尔尼大学免疫学教授、苏黎世大学客座教授，并且在Thurgau生物技术研究所担任科学顾问。早年他师从1996年诺贝尔生理及医学奖获得者罗夫·辛克纳吉Rolf M. Zinkernagel，和瑞士著名分子生物学Michael Hengartner。多年来他专注研究病原相关分子模式，并证明了免疫系统识别病原微生物非特异性结构的分子机制，这项理论为病毒和许多细菌的高免疫原性提供了解释。此后Martin教授又将病原相关分子模式理论进行了成果转化，被世界著名生物技术公司采用，其中包括诺华（Novartis）的阿尔茨海默症疫苗项目、辉瑞（Pfizer）的抗过敏疫苗项目和新加坡科技研究局A*Star的新型流感疫苗项目。目前这些项目都已经到达了临床验证阶段。
导师还开发了新的免疫表达系统、基于哺乳动物细胞展示的功能基因组学技术和分离全人类抗体的技术，在医学界具有非常高的学术水平。
Martin is a professor at the Nuffield Department of Medicine at the University of Oxford, he has demonstrated that highly repetitive structures enhance B cell responses by efficiently cross-linking B cell receptors as well as efficiently innervating the innate humoral immune system. This provides an explanation for the high immunogenicity of viruses and many bacteria. And use the concept of epitope repeatability as molecular PAMPs to develop new vaccine platforms.Novartis, Pfizer, and Singapore's A*Star have all conducted various clinical studies based on this technology. He has also developed new expression systems, functional genomics technology based on mammalian cell display, and technology for isolating fully human antibodies, and has a very high academic level in the medical community. He is also the head of the Department of Immunology at the Inselspital RIA in Bern, Switzerland, a professor of immunology at the University of Bern, and a visiting professor at the University of Zurich. He is the scientific advisory board of several companies and the scientific advisory board of the Thurgau Institute of Biotechnology.
项目背景
动物疫病危害严重，不仅引起大批动物发病和死亡，而且影响动物及其产品的安全和国际贸易，甚至对人类健康造成威胁，据报道约60%–80%的人类新发传染病(Emerging infectious diseases, EIDs)来源于动物。接种疫苗是预防和控制动物传染病最有效、最经济的策略之一。通过接种疫苗可以降低疫病的发病率、并发症和动物的死亡率，减少经济损失。尤其，宠物疫苗潜在空间达 106 亿元。从标准免疫程序来看，宠物犬每年需注射一针犬六联疫苗，根据进口品牌价格测算新生犬疫苗费用为 240 元，此后每年疫苗费用至少为 80 元；宠物猫每年需注射一针猫三联+狂犬病疫苗，新生猫疫苗费用为 280元，此后每年 140 元。若保守以当前全国 0.55 亿只宠物犬、0.44 亿只宠物猫为基数，同时考虑到出厂价格存在的折价，预计宠物疫苗潜在空间为 53 亿元，未来随着宠物数量的增长空间将更为广阔。
项目介绍
本项目旨在提供全面的免疫学基础知识和疫苗科学的最新进展。内容涵盖免疫学导论、疫苗的作用机制、动物疾病与疫苗、人类疾病与疫苗、针对慢性疾病的疫苗策略以及癌症疫苗。通过学习，学生将了解免疫系统的基本原理，疫苗如何激活免疫反应，动物和人类疾病的疫苗开发，以及针对慢性疾病和癌症的创新疫苗策略。本课程将结合理论与实际案例，帮助学生深入理解疫苗的设计、开发和应用，为未来的科研和临床实践打下坚实基础。学生将在项目结束时，提交项目研究报告，进行成果展示。 个性化研究课题参考： 动物病毒重组活载体疫苗研究进展 佐剂在牛病疫苗中的应用探究 淋巴瘤中免疫检查点抑制剂研究
The project aims to provide a comprehensive understanding of the fundamentals of immunology and the latest advancements in vaccine science. Topics include an introduction to immunology, mechanisms of vaccine action, animal diseases and vaccines, human diseases and vaccines, vaccine strategies for chronic diseases, and cancer vaccines. Through this course, students will learn about the basic principles of the immune system, how vaccines trigger immune responses, the development of vaccines for both animal and human diseases, and innovative vaccine strategies for chronic diseases and cancer. The course combines theoretical knowledge with practical case studies, helping students to deeply understand the design, development, and application of vaccines, laying a solid foundation for future research and clinical practice. At the end of the project, students will submit a project research report and present their results. Suggested Research Fields： Research progress of animal virus recombinant live vector vaccines Research on the application of adjuvant in bovine disease vaccine The Highs and Lows of Immune-Checkpoint Blockade in Lymphoma
项目大纲
免疫学导论：免疫的定义和类型、免疫系统防御机制、抗体的概念、免疫细胞及其类型、疫苗及疫苗的作用机制 Introduction to immunology: Definition and types of immunity, defense mechanism of immune system, concept of antibody, immune cells and their types, vaccines and mechanisms of action of vaccines
动物疾病与疫苗：细胞因子、细胞因子对免疫细胞的影响、细胞因子抗原疫苗、针对多种动物疾病的疫苗措施（马的虫咬过敏、狗的特应性皮炎、动物慢性疼痛、动物骨关节炎、猫过敏症等）Animal diseases and vaccines: cytokines, effects of cytokines on immune cells, cytokine antigen vaccines, vaccine measures against many animal diseases
人类疾病与疫苗：针对慢性疾病的疫苗策略（高血压、神经退行性疾病、糖尿病、尼古丁依赖症等）Human disease and vaccines: Vaccine strategies for chronic diseases
癌症疫苗：癌症疫苗的类型、癌症的免疫细胞疗法、案例学习：针对乳腺癌抗原疫苗、减少肺癌转移疫苗、人类乳头瘤病毒HPV疫苗、黑色素瘤疫苗等临床研究 Cancer vaccine: Types of cancer vaccine, immune cell therapy of cancer, case study:
项目回顾与成果展示 Program review and presentation
论文辅导 Project deliverable tutoring
项目收获
7周在线小组科研学习+5周不限时论文指导学习 共125课时
项目报告
优秀学员获主导师Reference Letter
EI/CPCI/Scopus/ProQuest/Crossref/EBSCO或同等级别索引国际会议全文投递与发表指导（可用于申请）
结业证书
成绩单
LASER Award in Research Skills for Academic Study官方证书并转换8 UCAS Tariff Points（可选）